Our research seeks to uncover the fundamental mechanisms through which mitochondrial biology preserves cellular and tissue function, and to understand how mitochondrial dysfunction propagates across biological scales—from molecular defects and loss of cellular fitness to tissue degeneration, organ failure and systemic metabolic disease. We are particularly interested in defining how mitochondrial dysfunction in glial cells drives neurodegeneration and reshapes systemic metabolism. Ultimately, our goal is to reveal new therapeutic strategies for mitochondrial and neurodegenerative disorders.

Metastatic cells encounter profoundly different physiological environments as they disseminate throughout the body. We seek to uncover the metabolic principles that determine why tumour cells colonise specific organs by defining the mechanisms that establish metabolic compatibility between metastatic cells and individual organs. We are particularly interested in understanding how these adaptive programmes are acquired, maintained and ultimately exploited as therapeutic vulnerabilities to prevent and treat metastatic disease.

Immune cells continuously adapt to the metabolic environments of the tissues they inhabit. We seek to uncover the metabolic principles through which tissue-specific ecosystems—and their progressive remodelling during ageing and disease—shape immune-cell function and anti-tumour immunity across metastatic organs. We are particularly interested in understanding how metabolic rewiring of tissue-resident immune cells, including brain microglia, influences metastatic progression and therapeutic responses. Ultimately, our goal is to identify new metabolic vulnerabilities to develop more effective immunotherapies and tissue-adapted cellular therapies.